Polycystic ovary syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting up to 10% of females of reproductive age. It is multifactorial disease Involves interactions between “nature” and “nurture”.
The most common endocrine aberrations seen in PCOS are chronically elevated luteinizing hormone (LH) and insulin resistance (IR).
It is interesting to note that high LH and hyperinsulinemia work synergistically, causing ovarian growth, androgen production, and ovarian cyst formation.
Weight loss is recommended as first-line therapy for the management of infertility in overweight and obese women with PCOS, since ovulation and pregnancy loss are linked with obesity (see Fitness and Fitness 100).
Myoinositol (MYO) and d-chiro-inositol (DCI) types have been well studied in women with PCOS, both showing good results. MI is the precursor of inositol triphosphate, a second messenger regulating many hormones such as TSH, FSH and insulin. DCI is synthesized by an insulin dependent epimerase that converts MI into DCI. MI and DCI are precursors of signalling molecules such as inositol phosphoglycans (I-PGs) which are important in insulin sensitization.
MI decreased level in the theca cells and Imbalance in MI/DCI ratio could be the cause of the poor oocyte quality and the impairment in the FSH signaling in PCOS women. Pre-treating PCOS women with MI supplementation before controlled ovarian hyperstimulation may improve oocyte and embryo quality and decrease “FSH resistance,” making the ovary more sensitive to FSH.
DCI reduces serum insulin and androgens, and improved some PCOS-associated metabolic abnormalities (increased blood pressure and hypertriglyceridemia). In addition, by using DCI it is possible to counteract insulin-resistance (i.e., the ovary is never insulin-resistant) by reducing insulin levels which may also indirectly benefit the ovary.
Recent reviews are emphasizing the concentrations of MI and DCI rather than the ratio between them.
MI and DCI combination Reduces androgen, Improves insulin resistance, Improves ovarian function and egg quality, regulates menstrual cycle, reduces weight, and improves lipid levels in the blood.
Cellucare contains 750 mg Myoinositol and 250 mg D-Chiroinositol.
Folic acid is being added to inositol therapy due to the increased fertility with women supplemented with inositol. The supplementation of folic acid around the time of conception reduces the risk of birth defects, and doesn’t seem to modify the influence of myo-inositol supplementation.
Quatrefolic represents the fourth generation folate derivatives. It acts as a nutrient in all areas where folic acid and folate supplementation has been recommended and allowed. Quatrefolic supplementation does not aid to the potential accumulation of folate in the blood, which has no biological function and whose effects are not yet known. Also Quatrefolic, as it provides the metabolic reduced folate form utilized and stored in the human body, may benefit certain genetic defects (10% of population) that influence folate metabolism. Furthermore, Quatrefolic is able to overcome the existing calcium salt form limitations related to stability, poor solubility and bioavailability.
Cellucare contains 400 mcg in each tablet.
Selenium importance in PCOS was discovered recently. A Study proved that women with PCOS have a decreased plasma concentration of Selenium (Se) compared to normal women. The study proved also a negative correlation between Se and LH, total testosterone. It was found that Se supplementation for PCOS women had decreased insulin level compared to placebo group. In addition, supplementation with Se resulted in a significant reduction in serum lipids.
DL-Selenomethionine is a Se analogue of Selenomethionine. It can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible Se storage in organs and tissues.
Cellucare contains 50mcg Selenomethionine in each tablet.
Vitamin B 12 is very important for maturation of ova and fetus growth. The use of metformin as first line therapy in PCOS reduces significantly the absorption of Vitamin B 12; hence it is a must to be supplemented for successful treatment.
Cellucare contains 25mcg Vitamin B12 in each tablet.